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Asian-American variant of human papillomavirus 16 E6 promotes the Warburg effect and hypoxia-inducible factor 1 signalling under hypoxia / by Sean Cuninghame.
Infection with high-risk human papillomavirus (HPV) is responsible for nearly all cases of cervical cancer, as well as a significant fraction of other ano-genital and head and neck cancers. Specifically, HPV type 16 (HPV ... -
Aspects of infectious agents and cancer : effects of human Papillomavirus 16 and Escherichia coli on the innate immune defense of human keratinocytes
(2012-11-10)Persistent human papillomavirus (HPV) is the causative agent of cervical cancer and bacterial vaginosis (BV) caused by Escherichia coli (E. coli ) has been implicated as a contributing factor. The innate immune system is ... -
The carcinogenic properties of naturally occurring human papillomavirus 16 E6 oncogene variants
(2013-02-03)Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical cancer, which is the result of expression of the E6 and E7 oncogenes. Here we challenged the dogma that the oncogenic protein ... -
A combined method for establishing keratinocyte cultures from cervical biopsy specimens and creating patent-derived 3-dimensional organotypic raft cultures
(2018)High-risk types of human papillomavirus (HPV) are responsible for nearly all instances of cervical cancer, and a significant proportion of head and neck cancers. Studying HPV in the laboratory requires the cultivation of ... -
Comparing Canonical and Dicer Substrate Small Interfering RNA and Their Effects on the Silencing of Two Common Human Papillomavirus 16 E6 Variants
(2015)High-risk human papillomaviruses (HPVs), such as HPV16, cause nearly all cases of cervical cancer as well as a number of head and neck cancers. Over expression of the E6 oncoprotein helps drive the malignant phenotype, ... -
Differential response of two common human papillomavirus 16 E6 variants to small interfering RNA
(2014-01-22)High-risk human papillomaviruses (HPVs), such as HPV16, are implicated in causing virtually all cases of cervical cancer. Molecular therapies capable of targeting HPV16 E6 oncoprotein expression can selectively eliminate ... -
Evaluation of Anti-E6 Single Domain Antibodies for the Treatment of Human Papillomavirus-related Cancer
(2022)The HPV16 genome encodes two oncoproteins, E6 and E7, which are essential for viral carcinogenesis. While E7 promotes cell proliferation, E6 abolishes the resulting p53-dependent apoptotic response. We hypothesized that ... -
Expression of integrin and toll-like receptors in cervical cancer (in vivo and ex vivo study)
(2009)Cervical cancer is the second most common cancer in women world-wide. Although persistent human papillomavirus (HPV) infection is considered the most important causative agent of cervical cancer, the mechanisms toward ... -
The life cycle of human papillomavirus type 16 E6 variants and its effects on the innate immune system of host keratinocytes
(2013-02-01)Persistent infection with human papillomavirus type 16 (HPV16) is the primary aetiological agent for cervical cancer. Viral particles initiate their life cycle by infecting basal keratinocytes of epithelium and amplifying ... -
Method optimization and gene expression analysis for interferon Kappa mRNA in HPV-associated cervical disease / by Correne A. Decarlo.
(2008)Interferons (IFNs) are a common biological treatment option for many cancers as well as for human papillomavirus (HPV)-associated diseases, but current IFN treatments have not been optimized as disease progression subsists ... -
Pathogen-host omics analyses of human papillomavirus type 16 sub-lineages in a human epithelial organoid model
(2019)Pathogens such as human papillomaviruses (HPVs) have co-evolved with their hosts and form a molecular basis for common diseases. Persistent infection with the “high-risk” HPV type 16 (HPV16) is a potent cause of anogenital ... -
Pull-down of human papillomavirus 16 E6 variants for interactome analysis: a methods development and analysis
(2020)Human Papillomavirus 16 (HPV16) is a double-stranded DNA virus known as a causative agent in almost all cervical cancers and an increasing number of oropharyngeal cancers. Variants of HPV16, such as the Asian-American ...
